They (n = 18/group) were randomly assigned into intervention groups to take either 200 μg/day of selenium or placebo for 8 weeks. Thirty-six women candidate for IVF were recruited in this randomized double-blinded, placebo-controlled trial. This study was performed to determine the effects of selenium supplementation on clinical symptoms and gene expression related to inflammatory markers in infertile women with polycystic ovary syndrome (PCOS) who were candidate for in vitro fertilization (IVF). In addition, this meta-analysis provides important reference opinions and treatment recommendations for PCOS. Omega-3 may be a more effective antioxidant intervention for PCOS. However, antioxidant intervention therapy has no discernible impact on testosterone levels or body mass index. This meta-analysis demonstrates the efficacy of antioxidant intervention in patients with PCOS, demonstrating that antioxidant intervention has a significant effect on insulin resistance and lipid metabolism improvement. Subgroup analysis showed that except for the D-chiro-inosito subgroup, no difference in body mass index was observed between the intervention group and the control group. And antioxidant intervention did not improve testosterone levels significantly (WMD = -0.20, P =. Antioxidant intervention had a positive impact on homeostasis model assessment of insulin resistance (WMD = -0.37, P =. Twenty-three studies were included in total. The analysis was conducted using Stata version 16.0. Data were reported as weighted mean difference (WMD) or standard mean difference with associated confidence intervals of 95%. In order to further clarify whether antioxidant therapy is beneficial for PCOS patients and the emphasis of its effects, this study provides a systematic review and meta-analysis of randomized controlled trials examining the effect of antioxidant intervention on PCOS.Įnrolled study designs related to antioxidant interventions and PCOS, published from 1999 to 2020, were searched from EMBASE, PubMed, and Web of Science databases to sort out proven studies on antioxidant interventions and PCOS. The role of antioxidant intervention in polycystic ovary syndrome (PCOS) patients has been increasingly investigated in recent years.
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